Got a friend asking for advice on how to get in contact with a publisher or agent. He's a first-timer wanting to sell a fantasy novel. I don't know, but I think I know people who could suggest where to start...
Have him look up a copy of The Writer's Market 2009 and he'll find a number of options. Most publishing companies don't take un-agented manuscripts, though.
Not 100% what you are looking for, but this might also be helpful to your friend. (Writing advice from a new author, whom I am hoping wins a Campbell @ the 2010 Worldcon.)
Many if not most genre publishers still accept unsolicted manuscripts. Have him check who publishes most of what he reads and send it there -- the theory being you write what you like to read.
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I recall her mentioning how to find an agent at one point too.